Review on various analytical methodologies for Azithromycin

Aakanksha Sinha; S. J. Daharwal*

doi:10.52228/NBW-JAAB.2022-4-1-5

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Review on various analytical methodologies for Azithromycin

Author(s): Aakanksha Sinha¹, S. J. Daharwal*²

Email(s): ¹, ²daharwalresearch@rediffmail.com

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Published In: Volume - 4, Issue - 1, Year - 2022

DOI: 10.52228/NBW-JAAB.2022-4-1-5

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ABSTRACT:
The azithromycin broad-spectrum macrolide antibiotic, is generally used to treat genitourinary, respiratory, and enteric infections. The development of analytical techniques and the different currently employed techniques for estimating azithromycin, both in pharmaceutical dose form or in bulk, are the primary focus of the current study. Analytical techniques are crucial for determining compositions as they allow us to employ state-of-the-art analytical equipment to collect both qualitative and quantitative data. Chromatographic, electrochemical, spectroscopic, and other methods can be used to analyse azithromycin. These methods aid in understanding key process factors and restricting the negative impact they have on accuracy and precision. Analytical technique development is required for maintaining high commercial product quality standards and to comply with rules and regulations. In response to the reference, regulatory bodies in various nations have developed policies and procedures for giving approval, authentication, and registration.

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Cite this article:
Aakanksha Sinha, S. J. Daharwal (2022) Review on various analytical methodologies for Azithromycin. NewBioWorld A Journal of Alumni Association of Biotechnology,4(1):20-27.DOI: https://doi.org/10.52228/NBW-JAAB.2022-4-1-5

Abou Assi, R., Darwis, Y., Abdulbaqi, I.M. and Asif, S.M., 2017. Development and validation of a stability-indicating RP-HPLC method for the detection and quantification of azithromycin in bulk, and self-emulsifying drug delivery system (SEDDs) formulation. Journal of Applied Pharmaceutical Science, 7(9), pp.020-029.

Afzal, S.J.S., Khan, P.M.A.A. and Baig, M.S., 2016. RP-HPLC analytical method development and validation for azithromycin and cefpodoxime in tablet dosage form.

Al-Hakkani, M.F., 2019. A rapid, developed and validated RP-HPLC method for determination of azithromycin. SN Applied Sciences, 1(3), p.222.

Ambati P, Bala Krishna P, Srinivasa Rao Y, Varaprasada Rao K and Deepthi R. 2021. Instrumentation and future prospectus of HPTLC-A. World Journal of Pharmaceutical Research Vol.10 Issue 6, 650-661

Babić, S., Horvat, A.J., Pavlović, D.M. and Kaštelan-Macan, M., 2007. Determination of pKa values of active pharmaceutical ingredients. TrAC Trends in Analytical Chemistry, 26(11), pp.1043-1061.

Baig, M.S., Anees, M.I., Muntasiruddin, K., Naeem, S. and Khan, J., 2015. Simultaneous estimation of azithromycin and cefpodoxime proxetil from its tablet dosage form by UV Visible spectroscopic methods. World Journal of Pharmacy and Pharmaceutical Sciences, 4, pp.1420-1430.

Bouklouze, A., Kharbach, M., Cherrah, Y. and Vander Heyden, Y., 2017, March. Azithromycin assay in drug formulations: Validation of a HPTLC method with a quadratic polynomial calibration model using the accuracy profile approach. In Annales Pharmaceutiques Francaises (Vol. 75, No. 2, pp. 112-120). Elsevier Masson.

Breaux J, Jones K and Boulas P. Analytical methods development and validation. Pharm. Technol. 2003; 1:6-13.

Chen, L., Qin, F., Ma, Y. and Li, F., 2007. Quantitative determination of azithromycin in human plasma by ultra-performance liquid chromatography–electrospray ionization mass spectrometry and its application in a pharmacokinetic study. Journal of Chromatography B, 855(2), pp.255-261.

Choemunng, A. and Na-Bangchang, K., 2010. An alternative liquid chromatography-mass spectrometric method for the determination of azithromycin in human plasma and its application to pharmacokinetic study. Journal of liquid chromatography and related technologies, 33(16), pp.1516-1528.

Dewan, I., Amin, T., Hossain, M.F., Hasan, M., Chowdhury, S.F., Gazi, M. and Islam, S.A., 2013. Development and validation of a new HPLC method for the estimation of azithromycin in bulk and tablet dosage form. Int J Pharm Sci Res, 4(1), pp.282-286.

Djokić, S., Kobrehel, G., Lazarevski, G., Lopotar, N., Tamburašev, Z., Kamenar, B., Nagl, A. and Vicković, I., 1986. Erythromycin series. Part 11. Ring expansion of erythromycin A oxime by the Beckmann rearrangement. Journal of the Chemical Society, Perkin Transactions 1, pp.1881-1890.

El-Yazbi, A.F., Khamis, E.F., Youssef, R.M., El-Sayed, M.A. and Aboukhalil, F.M., 2020. Green analytical methods for simultaneous determination of compounds having relatively disparate absorbance; application to antibiotic formulation of azithromycin and levofloxacin. Heliyon, 6(9), p.e04819.

European Pharmacopoeia, edition vol. 16. 2005,1649.

FJ, SDH and Nieman DA, Introduction to UV Spectroscopy in Principle of Instrumental Analysis. 2004, 5th ed., Thomson book/Cole, 156.

Gawande, V.T., Bothara, K.G. and Satija, C.O., 2018. Validated stability-indicating HPTLC method for cefixime and azithromycin with preparative isolation, identification, and characterization of degradation products. Acta Chromatographica, 30(4), pp.212-218.

Greenwood, D., 2008. Antimicrobial Drugs: Chronicle of a Twentieth Century Medical Triumph. OUP Oxford.

Gulhane, C.A., Motule, A.S., Manwar, J.V., Sawarkar, H.S., Ajmire, P.V. and Bakal, R.L., 2021. UV-Visible Spectrophotometric estimation of azithromycin and cefixime from tablet formulation by area under curve method. World Journal of Pharmaceutical Sciences, pp.163-168.

Gundala, U., Bonagiri, C. and Nayakanti, D., 2014. Simultaneous estimation of azithromycin and cefixime in bulk and pharmaceutical formulation by Reverse Phase High Performance Liquid Chromatography (RP-HPLC), World Journal of Pharmaceutical Research Vol.3.

Gunjal Sanket, B and Dighe, PR, Analysis of herbal drugs by HPTLC: A review. Asian Journal of Pharmaceutical Research. 2022;10(2):125-8.

Haleem, D., Shireen, E., Haleem, M., Kaye, W., Bailer, U., Frank, G., Wagner, A. and Henry, S., 2006. Degradation studies of azithromycin and its spectrophotometric determination in pharmaceutical dosage forms. Pak. J. Pharm. Sci, 19(2), pp.98-103.

Hinge, M.A., Desai, N.A., Mahida, R.J. and Dalvadi, H.P., 2015. Spectrophotometric and High-Performance Liquid Chromatographic Determination of Ofloxacin and Azithromycin in Pharmaceutical Tablets. Pharmaceutical Methods, 6(1), p.26.

https://pubchem.ncbi.nlm.nih.gov/#query=azithromycin.

Kamble, R.N., Kumar, A.P. and Mehta, P.P., 2015. RP-HPLC Analytical Method Development and Validation for Azithromycin and Levofloxacin in Tablet Dosage Form. Int. J. Pharm. Sci. Rev. Res, 31, pp.162-165.

Magar, S.D., Tupe, A.P., Pawar, P.Y. and Mane, B.Y., 2012. Simultaneous spectrophotometric estimation of cefixime and azithromycin in tablet dosage form. Journal of Current Pharma Research, 2(3), p.535.

Malhotra, D., KALIA, A. and Tomar, S., 2011. Validated UV spectroscopic method for simultaneous estimation of Azithromycin and Prednisolone. International Journal of Pharmacy and Pharmaceutical Sciences, 3, pp.299-302.

Mallah, M.A., Sherazi, S.T.H., Mahesar, S.A. and Rauf, A., 2011. Assessment of azithromycin in pharmaceutical formulation by Fourier-transform infrared (FT-IR) transmission spectroscopy. Pakistan Journal of Analytical and Environmental Chemistry, 12(1 and 2), p.7.

Marvig, R.L., Søndergaard, M.S., Damkiær, S., Høiby, N., Johansen, H.K., Molin, S. and Jelsbak, L., 2012. Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 56(8), pp.4519-4521.

Nagaraju, K. and Chowdary, Y.A., 2018. Analytical Method Development and Validation for The Simultaneous Estimation of Azithromycin and Cefixime by RP-HPLC Method in Bulk and Pharmaceutical Formulations. International Journal of Research in Science and Technology, Vol. 4.

Omara, H.A., Ahmed, H.A., El-Mahdy, A.A. and Musbah, S.A., 2014. New spectrophotometric determination of azithromycin in pure and dosage forms using N-bromosuccinimide and potassium permanganate as oxidants. World J. of Pharmacy and Pharmaceutical Sciences, 3(4), pp.100-112.

Padmavathi, K. and Rao, M.S., 2015. A new validated RP-HPLC method for the simultaneous determination of ambroxol and azithromycin in combined dosage form. Bulletin of Pharmaceutical and Medical Sciences (BOPAMS), 3(4).

Pereyre, S., Renaudin, H., Charron, A., Bébéar, C. and Bébéar, C.M., 2006. Emergence of a 23S rRNA mutation in Mycoplasma hominis associated with a loss of the intrinsic resistance to erythromycin and azithromycin. Journal of Antimicrobial Chemotherapy, 57(4), pp.753-756.

Pharmacopeia, Indian. Vol-I and II Indian Pharmacopeia Commission. Ghaziabad, Govt of India Ministry of Health and Family Welfare. 2010: 861-62.

Raja, M.S., Shan, S.H., Moorthy, S. and Perumal, P., 2010. RP-HPLC method development and validation for the simultaneous estimation of azithromycin and ambroxol hydrochloride in tablets. International Journal of Pharm Tech Research, 2(1), pp.36-9.

Raval, P.L., Mehta, F.A., Ahir, K.B. and Bhatt, K.K., 2014. Simultaneous estimation of azithromycin dihydrate and cefixime trihydrate in pharmaceutical formulation by HPTLC method. Journal of Liquid Chromatography and Related Technologies, 37(13), pp.1805-1818.

Ravisankar P, Gowthami S and Rao GD. A review on analytical method development. Indian Journal of Research in Pharmacy and Biotechnology. 2014;2(3):1183.

Ravisankar P, Navya CN, Pravallika D and Sri DN. A review on step-by-step analytical method validation. IOSR J Pharm. 2015;5(10):7-19.

Sahoo, D.K. and Sahu, P.K., 2015. Chemometric approach for RP-HPLC determination of azithromycin, secnidazole, and fluconazole using response surface methodology. Journal of Liquid Chromatography and Related Technologies, 38(6), pp.750-758.

Sahu, A., Jatavb, M.P., Vinodec, R. and Yadavd, K., 2015. Development and validation of a reversedphase HPLC method for simultaneous estimation of azithromycin in tablet dosage form. International Journal Pharmaceutical Chemistry, 5, p.09.

Shah, V. and Raj, H., 2012. Development and validation of derivative spectroscopic method for simultaneous estimation of cefixime trihydrate and azithromycin dihydrate in combined dosage form. International Journal of Pharmaceutical Sciences and Research, 3(6), p.1753.

Shaikh, K.A., Patil, S.D. and Devkhile, A.B., 2008. Development and validation of a reversed-phase HPLC method for simultaneous estimation of ambroxol hydrochloride and azithromycin in tablet dosage form. Journal of Pharmaceutical and Biomedical Analysis, 48(5), pp.1481-1484.

Sharma A, Shanker C, Tyagi LK, Singh M and Rao CV 2008. Herbal medicine for market potential in India: an overview. Academy Journal of Plant Sci.;1(2):26-36.

Singlas, E., 1995. Clinical Pharmacokinetics of Azithromycin. Pathologie-Biologie, 43(6), pp.505-511.

Vennela, K., Reddy, M.M. and Subramanian, S., 2014. A New RP-HPLC Method for the Simultaneous Estimation of Azithromycin and Levofloxacin in it’s Pure and Pharmaceutical Dosage Form as per ICH Guidelines. International Journal of Pharma Research and Health Sciences Volume 2 (6), Page-507-513.

Verma G and Mishra M. Development and optimization of UV-VIS spectroscopy-a review. World Journal of Pharmaceutical Research. 2018;7(11):1170-1180.

Yandamuri N, Srinivas Nagabattula KR, Kurra SS, Batthula S, Nainesha Allada LPS and Bandam P. Comparative study of new trends in HPLC: a review. International Journal of Pharmaceutical Sciences Review and Research.2013; 23:52-57.

Zotou A. An overview of recent advances in HPLC Instrumentation. Open Chemistry. 2012;10(3):554-569.

Zubata, P., Ceresole, R., Rosasco, M.A. and Pizzorno, M.T., 2002. A new HPLC method for azithromycin quantitation. Journal of Pharmaceutical and Biomedical Analysis, 27(5), pp.833-836.

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