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Author(s): Harsha Verma11, 22, *3

Email(s): 1vermaharsha465@gmail.com


    1Govt. Nagarjuna PG College of Science, Raipur, Chhattisgarh, India
    22School of Studies in Biotechnology, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, India
    *Corresponding Author Email- vermaharsha465@gmail.com

Published In:   Volume - 2,      Issue - 2,     Year - 2020

DOI: 10.52228/NBW-JAAB.2020-2-2-5  

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Fluorescence In-Situ Hybridization (FISH) introduced in the 1980s, is a technique useful in gene mapping, detection of various types of abnormalities, such as fusion of genes and genomic fusion and deletions. Gradual implemented improvements have led to more precise patient diagnostics along with matching the best therapies. This technique has been now especially used in the field of cancer diagnostics and treatment. Some excellent examples discussed below include genetic tests like ALK and ROS1 gene performed in lung cancer.

Cite this article:
Harsha Verma (2020) Use of Fluorescence In-Situ Hybridization (FISH) in Diagnosis of Cancer. NewBioWorld A Journal of Alumni Association of Biotechnology, 2(2):18-20.DOI: https://doi.org/10.52228/NBW-JAAB.2020-2-2-5

Asif A, Mushtaq S, Hassan U, Akhtar N, Hussain M, Azam M, Qazi R (2018) Fluorescence in Situ Hybridization (FISH) for Differential Diagnosis of Soft Tissue Sarcomas. Asian Pac. J. Cancer Prev. APJCP, 19:655–660.

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Mertens F, Antonescu CR, Mitelman F (2016) Gene fusions in soft tissue tumors: recurrent and overlapping pathogenetic themes, The Journal of Pathology Clinical Research, 55: 291– 310.

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Salido M, Pijuan L, Martínez-Avilés L, Galván A.B, Cañadas I, Rovira A, Zanui M, Martínez A (2011) Increased ALK Gene Copy Number and Amplification Are Frequent in Non-Small Cell Lung Cancer. J. Thorac. Oncol. Off. Publ. Int. Assoc. Study Lung Cancer, 6:21–27. 

Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, Levin WJ, Stuart SG, Udove J, Ullrich A (1989) Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science, 244:707-12.

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