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Author(s): Rohini R Nair*1

Email(s): 1rohini.nair07@gmail.com

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    1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    *Corresponding Author Email- rohini.nair07@gmail.com

Published In:   Volume - 3,      Issue - 1,     Year - 2021

DOI: 10.52228/NBW-JAAB.2021-3-1-5  

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ABSTRACT:
Genomic integrity of sperm with stable epigenetic modification is essential for the successful pregnancy outcome. As sperm is subjected to varying degree of chromatin remodeling and regulation its susceptibility for the introduction of various types of errors also increases. Unstable sperm genome and epigenome may arise from improper genome reorganization, altered regulation during spermatogenesis, embryo development and exposures to environmental factors. Introduction of assisted reproductive technologies (ART) has increased our understanding of the role of paternal factors in successful pregnancy. Understanding of the sperm genetic and epigenetic factors is imperative for the improvement of methods in ART, which has far-reaching implications for human reproductive health.

Cite this article:
Rohini R Nair (2021) Genetic and Epigenetic reprogramming in sperm. NewBioWorld A Journal of Alumni Association of Biotechnology, 3(1):18-22.DOI: https://doi.org/10.52228/NBW-JAAB.2021-3-1-5


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Author(s): Rohini R Nair*

DOI: 10.52228/NBW-JAAB.2021-3-1-5         Access: Open Access Read More